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FrPbAII

General Description

NameValue
LevelS-1 / C-1
Discovered—- / —
SynonymParawixin 2
Molecular formulaC₆H₁₄N₄O₂
CAS764724-17-6
SMILESNC(C(N)CCCNC(N)=O)=O
InChIInChI=1S/C6H14N4O2/c7-4(5(8)11)2-1-3-10-6(9)12/h4H,1-3,7H2,(H2,8,11)(H3,9,10,12)
Precursor 1 [M+H]⁺175.11895
Precursor 2 [M+Na]⁺197.10090
Precursor 3 [2M+H]⁺349.23063
Precursor 4 [2M+Na]⁺371.21257
HDX7
Precursor HDX 1 [M(D₇)+D]⁺183.16917
Precursor HDX 2
Precursor HDX 3
Rt1.15
Rt HDX

MS/MS fragments

m/zMolecular formulaAnnotation
175.11895C₆H₁₅N₄O₂[M+H]⁺
158.09240C₆H₁₂N₃O₂[M+H-NH₃]⁺
141.06585C₆H₉N₂O₂[M+H-2NH₃]⁺
115.08659C₅H₁₁N₂O[M+H-H₂NCONH₂]⁺
113.07094C₅H₉N₂O
99.01890C₃H₃N₂O₂
98.06004C₅H₈NO[M+H-H₂NCONH₂-NH₃]⁺
86.06004C₄H₈NO
70.06513C₄H₈N

Recorded MS/MS spectra

pdfPrecursorCo-elutingSpiderSourceAuthor
Data175.11895FrPbAIIBiotrendY. M. Forster

References

TitleReferenceSpiderNameContentLink
Neurochemical characterization of a neuroprotective compound from Parawixia bistriata spider venom that inhibits synaptosomal uptake of GABA and glycineR.O. Beleboni, R. Guizzo, A. C. K. Fontana, A. B. Pizzo, R. O. G. Carolino, L. Gobbo-Neto, N. P. Lopes, J. Couthinho-Netto, W. F. dos Santos, Mol. Pharmacol. 2006, 69, 6, 1998-2006P. bistriataParawixin2 / FrPbAIIMS/MSLink
Anticonvulsant and anxiolytic activity of FrPbAII, a novel GABA uptake inhibitor isolated from the venom of the social spider Parawixia bistriata (Araneidae: Araneae)J. L. Liberato, A. O. S. Cunha, M. R. Mortari, E. A. Gelfuso, E. O. Beleboni, J. Coutinho-Netto, W. F. dos Santos, Brain Res. 2006, 1124, 1, 19-27P. bistriataFrPbAIILink
Neuropharmacological profile of FrPbAII, purified from the venom of the social spider Parawixia bistriata (Araneae, Araneidae), in Wistar ratsE. A. Gelfuso, A. O. S. Cunha, M. R. Mortari, J. L. Liberato, K. H. Paraventi, R. O. Beleboni, J. Coutinho-Netto, N. P. Lopes, W. F. dos Santos, Life Sci. 2007, 80, 6, 566-572P. bistriataFrPbAIILink
Parawixin2, a novel non-selective GABA uptake inhibitor from Parawixia bistriata spider venom, inhibits pentylenetetrazole-induced chemical kindling in ratsE. A. Gelfuso, J. L. Liberato, A. O. S. Cunha, M. R. Mortari, R. O. Beleboni, N. P. Lopes, W. F. dos Santos, Neurosci. Lett. 2013, 543, 12-16P. bistriataParawixin2Link
Disease modifying effects of the spider toxin Parawixin2 in the experimental epilepsy modelL. D. Godoy, J. L. Liberato, M. V. B. Celani, L. Gobbo-Neo, N. P. Lopes, W. F. dos Santos, Toxins 2017, 9, 9, 262-280P. bistriataParawixin2Link
Elucidation of the structure and synthesis of neuroprotective low molecular mass compounds of the Parawixia bistriata spider venomY. M. Forster, J. L. Green, A. Khatiwada, J. L. Liberato, P. A. Narayana Reddy, J. M. Salvino, S. Bienz, L. Bigler, W. Ferreira dos Santos, A. C. K. Fontana, 2020, in preparationP. bistriatanot part of the spider venom (see arginine)ESI-MS/MS, Activity studiesLink

Spider species

Spider speciesFamiliyDiscovered

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