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Histamine

General Description

NameValue
LevelS-1 / C-1
Discovered1957 / L. erythrognatha & P. fera
Synonym
Molecular formulaC₅H₉N₃
CAS51-45-6
SMILESNCCC1=CNC=N1
InChIInChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
Precursor 1 [M+H]⁺112.08692
Precursor 2
Precursor 3
HDX3
Precursor HDX 1 [M(D₃)+D]⁺116.11203
Precursor HDX 2
Precursor HDX 3
Rt1.09
Rt HDX1.06

MS/MS fragments

m/zMolecular formulaAnnotation
112.08692C₅H₁₀N₃[M+H]⁺
95.06037C₅H₇N₂[M+H-NH₃]⁺
83.06037C₄H₇N₂
68.04948C₄H₆N

Recorded MS/MS spectra

pdfPrecursorCo-elutingSpiderSourceAuthor
Data112.08692Histamine 2HCl (CAS 56-92-8)FlukaY. M. Forster
Data112.08692Alopecosa sp.1Fauna Laboratories Ltd., KAZY. M. Forster
Data112.08692Alopecosa sp.4Fauna Laboratories Ltd., KAZY. M. Forster
Data112.08692Alopecosa sp.5Fauna Laboratories Ltd., KAZY. M. Forster
Data112.08692Desertosa sp.3Fauna Laboratories Ltd., KAZY. M. Forster
Data112.08692Geolycosa sp.Spider Pharm, USAY. M. Forster
Data112.08692Hippocosa sp.1Fauna Laboratories Ltd., KAZY. M. Forster
Data112.08692H. carolinensisSpider Pharm, USAY. M. Forster
DataHDXH. carolinensisSpider Pharm, USAY. M. Forster
Data112.08692L. praegrandisFauna Laboratories Ltd., KAZY. M. Forster
Data112.08692Lycosa sp.1Fauna Laboratories Ltd., KAZY. M. Forster
Data112.08692Lycosa sp.3Fauna Laboratories Ltd., KAZY. M. Forster
Data112.08692Lycosa sp.4Fauna Laboratories Ltd., KAZY. M. Forster
Data112.08692Lycosa sp.5Fauna Laboratories Ltd., KAZY. M. Forster
Data112.08692P. viridansSpider Pharm, USAY. M. Forster

References

TitleReferenceSpiderNameContentLink
The venom of the Brazilian tarantula, Lycosa erythrognatha, and the spider, Phoneutria feraF. G. Fischer, H. Bohn, Hoppe Seylers Z. Physiol. Chem. 1957, 306, 265-268L. erythrognatha & P. feraLink
Phoneutria nigriventer venom. Pharmacology and biochemistry of its componentsIn: Venomous animals and their venoms (New York: Academic Press, 1973), S. Schenberg, F. A. Pereira-LimaP. nigriventer
Preliminary studies on the venom of three Indian spiderG. Ridling Margaret, G. J. Phanuel, Proc. Indian Acad. Sci. 1988, 97, 3, 231-237L. indagatrixpaper chromatographyLink
Determination of biogenic amines in spider venom glands of nine typical Japanese species and chromatographic elution pattern analysis of venomous componentsK. Hagiwara, A. Tokita, A. Miwa, N. Kawai, Y. Murata, A. Uchida, T. Nakajima, Jpn. J. Sanit. Zool. 1991, 42, 2, 77-84C. japonicumLink
Purification of toxic peptides and the amino acid sequence of CSTX-1 from the multicomponent venom of Cupiennius salei (Araneae: Ctenidae)L. Kuhn-Nentwig, J. Schaller, W. Nentwig, Toxicon 1994, 32, 3, 287-302C. saleiLink
Quantity and quality of venom released by a spider (Cupiennius salei, Ctenidae)J.-L. Boeve, L. Kuhn-Nentwig, S. Keller, W. Nentwig, Toxicon 1995, 33, 10, 1347-1357C. saleiLink
Taurine and histamine: Low molecular compounds in prey hemolymph increase the killing power of spider venomL. Kuhn-Nentwig, A. Bücheler, A. Studer, W. Nentwig, Naturwissenschaften 1998, 85, 3, 136-138Link
Evidence that histamine is the principal pharmacological component of venom from an Australian wolf spider (Lycosa godeffroyi)L. D. Rash, R. G. King, W. C. Hodgson, Toxicon 1998, 36, 2, 367-375L. godeffroyiLink
Sex differences in the pharmacological activity of venom from the white-tailed spider (Lampona cylindrata)L. D. Rash, R. G. King, W. C. Hodgsen, Toxicon 2000, 38, 8, 1111-1127L. cylindrataLink
Spider venom: enhancement of venom efficacy mediated by different synergistic strategies in Cupiennius saleiB. Wullschleger, W. Nentwig, L. Kuhn-Nentwig, J. Exp. Biol. 2005, 208, 2115-2121C. saleiLink
Chromatographic analysis of large numbers of marine bacterial extracts and the venom of the spider Cupiennius saleiK. Böröczky, PhD-Thesis, Technische Universität Carolo-Wilhelmina zu Braunschweig, 2005C. saleiGC-MSLink
NMR-spectroscopic screening of spider venom reveals sulfated nucleosides as major components for the brown recluse and related speciesF. C. Schroeder, A. E. Taggi, M. Gronquist, R. U. Malik, J. B. Grant, T. Eisner, J. Meinwald, PNAS 2008, 105, 14283-14287div.NMR-screeningLink
Mass spectrometric characterisation and quantification of selected low molecular mass compounds from the venom of Haplopelma lividum (Theraphosidae)S. Moore, W. F. Smyth, V. A. Gault, E. O’Kane, S. McClean, Rapid Commun. Mass. Spectrom. 2009, 23, 1747-1755C. lividumHPLC-ESI-MS/MSLink
Inflammatory events induced by brown spider venom and its recombinant dermonecrotic toxin: A pharmacological investigationK. S. Paludo, S. M. P. Biscaia, O. M. Chaim, M. F. Otuki, K. Naliwaiko, P. A. Dombrowski, C. R. C. Franco, S. S. Veiga, Comparative Biochemistry and Physiology, Part C 2009, 149, 3, 323-333L. intermediaNameContentLink

Spider species

Spider speciesFamilyDiscovered
Alopecosa sp.Lycosidae2020 / Y. M. Forster
Cheiracanthium japonicumCheiracanthiidae1991 / K. Hagiwara
Cupiennius saleiCupiennius1994 / L. Kuhn-Nentwig
Cyriopagopus lividumTheraphosidae2008 / F. C. Schroeder
Desertosa sp.Lycosidae2020 / Y. M. Forster
Eusparassus oculatusSparassidae2008 / F. C. Schroeder
Geolycosa sp.Lycosidae2020 / Y. M. Forster
Hippocosa sp.Lycosidae2020 / Y. M. Forster
Hogna carolinensisLycosidae2020 / Y. M. Forster
Lampona cylindrataLamponidae2000 / L. D. Rash
Loxosceles intermediaSicariidae2009 / K. S. Paludo
Lycosa erythrognathaLycosidae1957 / F. G. Fischer
Lycosa indagatrixLycosidae1988 / G. Ridling Margaret
Lycosa praegrandisLycosidae2008 / F. C. Schroeder
Lycosa sp.Lycosidae2020 / Y. M. Forster
Neoscona nauticaAraneidae1991 / K. Hagiwara
Peucetia viridansOxyopidae2020 / Y. M. Forster
Phidippus sp.Salticidae2008 / F. C. Schroeder
Phoneutria feraCtenidae1957 / F. G. Fischer
Phoneutria nigriventerCtenidae1973 / S. Schenberg
Tasmaniocosa godeffroyiLycosidae1998 / L. D. Rash

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