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FTX

General Description

Name	Value
Level	S-5 / C-4
Discovered	1989 / A. aperta
Synonym
Molecular formula
CAS
SMILES
InChI

Precursor 1 [M+H]⁺
Precursor 2 [M+2H]²⁺
Precursor 3

HDX
Precursor HDX 1 [d-M+D]⁺
Precursor HDX 2 [d-M+2D]²⁺
Precursor HDX 3

Rt
Rt HDX

Calculated MS/MS fragments

#	a	b	c	ta	z	y	tz

Additional MS/MS fragments

m/z	Annotation

Recorded MS/MS spectra

pdf	Precursor	Co-eluting	Spider	Source	Author

References

Title	Reference	Spider	Name	Content	Link
Blocking and isolation of a calcium channel from neurons in mammals and cephalopods utilizing a toxin fraction (FTX) from funnel-web spider poison	R. Llinas, M. Sugimori, J. W. Lin, B. Cherksey, PNAS 1989, 86, 1689-1693.	A. aperta	FTX		Link
Properties of calcium channels isolated with spider toxin, FTX	B. D. Cherksey, M. Sugimori, R. R. Llinas, Ann. N. Y. Acad. Sci. 1991, 635, 1, 80-89	A. aperta	FTX		Link
Distribution and functional significance of the P-type, voltage-dependent Ca2+ channels in the mammalian central nervous system	R. Llinas, M. Sugimori, D. E. Hillman, B. Chersky, Trends Neurosci. 1992, 15, 9, 351-355	A. aperta	FTX		Link
Agelenopsis aperta venom and FTX, a purified toxin, inhibit acetylcholine release i Torpedo synaptosomes	N. Moulian, Y. Morot Gaudry-Talarmain, Neuroscience 1993, 54, 1035-1041.	A. aperta	FTX	Activity-studies	Link
Practical synthesis of the putative polyamine spider toxin FTX: a proposed blocker of voltage-sensitive calcium channels	I. S. Blagbrough, E. Moya, Tetrahedron Lett. 1994, 35, 13, 2057-2060		FTX		Link
Pharmacological identification of a novel Ca2+ channel in chicken brain synaptosomes	P. M. Lundy, M. G. Hamilton, R. Frew, Brain Research 1994, 643, 1-2, 201-210		FTX		Link

Spider species

Spider species	Family	Discovered
Agelenopsis aperta	Agelenidae	1989 / R. Llinas

Comments

FTX is a unknown compound (200 - 400 Da), probably a polyamine with a C:N ratio of 2:1. May contain guanidino moiety. No oxygen.