venoMS

Navigation :

IndAcAsn5

General Description

Name	Value
Level	S-3 / C-1
Discovered	? / A. lobata
Synonym	Arg 373 / Pseudoargiopinin 3
Molecular formula	C₁₉H₂₇N₅O₃
CAS	152886-77-6 (S) / 175777-87-4 ®
SMILES	`O=C(NC(CC(N)=O)C(NCCCCCN)=O)CC1=CNC2=C1C=CC=C2`
InChI	`InChI=1S/C19H27N5O3/c20-8-4-1-5-9-22-19(27)16(11-17(21)25)24-18(26)10-13-12-23-15-7-3-2-6-14(13)15/h2-3,6-7,12,16,23H,1,4-5,8-11,20H2,(H2,21,25)(H,22,27)(H,24,26)`

Precursor 1 [M+H]⁺	374.21867
Precursor 2 [M+2H]²⁺	187.61297
Precursor 3

HDX	7
Precursor HDX 1 [M(D₇)+D]⁺	382.26888
Precursor HDX 2 [M(D₇)+2D]²⁺	192.14122
Precursor HDX 3

Rt	12.10
Rt HDX	10.87

Calculated MS/MS fragments

#	a	b	c	ta	z	y	tz
1	272.10297	254.09240	255.07642	289.12952	86.09643	69.06988	103.12297
2	357.19212	339.18155	340.16557	374.21867	200.13935	183.11280	217.16590

Additional MS/MS fragments

m/z	Annotation
130.06513	a’
158.06004	a0

Recorded MS/MS spectra

pdf	Precursor	Co-eluting	Spider	Source	Author
Data	374.21867		P. bistriata	Prof. Dr. Wagner Ferreira dos Santos, BRA	Y. M. Forster
Data	HDX		P. bistriata	Prof. Dr. Wagner Ferreira dos Santos, BRA	Y. M. Forster

References

Title	Reference	Spider	Name	Content	Link
Glutamate receptor anatgonists from the spider Argiope lobata venom	E. V. Grishin, T. M. Volkova, A. S. Arseniev, Biorg. Khim. 1988, 14, 883-892
Isolation and structure analysis of components from venom of the spider Argiope lobata	E. V. Grishin, T. M. Volkova, A. S. Arseniev, Toxicon 1989, 27, 541-549	A. lobata	Pseudoargiopinin 3	FAB-MS, NMR (ns), Amino acid analysis, Activity-studies	Link
Argiopine, argiopinines, and pseudoargiopinines as glutamate receptor blockers in hippocampal neurons	N. I. Kiskin, O. A. Kryshtal, A. Ya. Tsyndrenko, T. M. Volkova, E. V. Grishin, Neurophysiology 1990, 21, 525-532	A. lobata	Pseudoargiopinin 3	Activity-studies	Link
Antropod toxins as leads for novel insecticides: An assessment of polyamine amides as glutamate antagonists	I. S. Blagbrough, P. T. H. Brackley, M. Bruce, B. W. Bycroft, A. J. Mather, S. Millington, H. L. Sudan, P. N. R. Usherwood, Toxicon 1992, 30, 303-322		Pseudoargiopinin 3	Activity-studies	Link
Polyamine toxins from spiders and wasps	A. Schäfer, H. Benz, W. Fiedler, A. Guggisberg, S. Bienz, M. Hesse, The Alkaloids 1994, 45, 1-125	A. lobata	Arg 373	Review	Link
Solid-phase synthesis of peptide aminoalkylamides using an allyl linker	K. Kaljuste, A. Unden, Tetrahedron Letters 1996, 37, 3031-3034	—	Pseudioargiopinin 3 (7)	Synthesis, NMR	Link
Versatile Dde-based primary amine linkers for solid phase synthesis	S. R. Chhabra, A. N. Khan, B. W. Bycroft, Tetrahedron Letters 1998, 39, 3585-3588	—	Pseudoargiopinin 3 (7)	Synthesis, NMR (ns)	Link
Total synthesis of NPTX-643, a neurotoxin of the Madagascar spider (Nephilengys borbonica) having a novel acylpolyamine structure	M. Miyashita, T. Kanemura, M. Matsushita, S. Hatakeyama, Y. Itagaki, T. Nakajima, M. Miyazawa, H. Irie, Heterocycles 1998, 47, 171-175	—		Synthesis	Link
Acylpolyamines: Mass spectrometric analytical methods for Araneidae spider acylpolyamines	Y. Itagaki , T. Nakajima , Toxin Rev. 2000, 19, 23-52	A. lobata	Arg 373	Review	Link
Elucidation of the structure and synthesis of neuroprotective low molecular mass components of the Parawixia bistriata spider venom	Y. M. Forster, J. L. Green, A. Khatiwada, J. L. Liberato, P. A. Narayana Reddy, J. M. Salvino, S. Bienz, L. Bigler, W. Ferreira dos Santos, A. C. K. Fontana, ACS Chem Neurosci., 2020	P. bistriata		ESI-MS/MS	Link

Spider species

Spider species	Family	Discovered
Argiope lobata	Araneidae	? / ?
Parawixia bistriata	Araneidae	2020 / Y. M. Forster

Comments