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4-OH-IndAcLysMe53Arg
General Description
| Name | Value |
|---|
| Level | S-4 / C-3 |
| Discovered | 1988 / A. lobata |
| Synonym | Arg 630 / Argiopinin 4 |
| Molecular formula | C₃₁H₅₄N₁₀O₄ |
| CAS | 117233-43-9 |
| SMILES | O=C(NC(CCCCNC)C(NCCCCCNCCCNC(C(N)CCCNC(N)=N)=O)=O)CC1=CNC2=C1C(O)=CC=C2 |
| InChI | InChI=1S/C31H54N10O4/c1-35-14-6-3-11-25(41-27(43)20-22-21-40-24-12-7-13-26(42)28(22)24)30(45)38-17-5-2-4-15-36-16-9-19-37-29(44)23(32)10-8-18-39-31(33)34/h7,12-13,21,23,25,35-36,40,42H,2-6,8-11,14-20,32H2,1H3,(H,37,44)(H,38,45)(H,41,43)(H4,33,34,39) |
| |
| Precursor 1 [M+H]⁺ | 631.44023 |
| Precursor 2 [M+2H]²⁺ | 316.22375 |
| Precursor 3 | |
| |
| HDX | 13 |
| Precursor HDX 1 [M(D₁₃)+D]⁺ | 645.52810 |
| Precursor HDX 2 [M(D₁₃)+2D]²⁺ | 323.77083 |
| Precursor HDX 3 | |
| |
| Rt | |
| Rt HDX | |
Calculated MS/MS fragments
| # | a | b | c | ta | z | y | tz |
|---|
| 1 | 316.16557 | 298.15500 | 299.13902 | 333.19212 | 214.16624 | 197.13969 | 231.19279 |
| 2 | 401.25472 | 383.24415 | 384.22817 | 418.28127 | 299.25539 | 282.22884 | 316.28194 |
| 3 | 458.31257 | 440.30200 | 441.28602 | 631.44023 | 441.36600 | 424.33945 | 458.39255 |
Additional MS/MS fragments
| m/z | Annotation |
|---|
| 146.06004 | a’ |
| 174.05495 | a0 |
Recorded MS/MS spectra
| pdf | Precursor | Co-eluting | Spider | Source | Author |
|---|
| | | | | |
References
| Title | Reference | Spider | Name | Content | Link |
|---|
| Glutamate receptor anatgonists from the spider Argiope lobata venom | E. V. Grishin, T. M. Volkova, A. S. Arseniev, Biorg. Khim. 1988, 14, 883-892 | A. lobata | | | |
| Isolation and structure analysis of components from venom of the spider Argiope lobata | E. V. Grishin, T. M. Volkova, A. S. Arseniev, Toxicon 1989, 27, 541-549 | A. lobata | Argiopinin 4 | NMR (ns), Amino acid analysis, Activity-studies | Link |
| Argiopine, argiopinines, and pseudoargiopinines as glutamate receptor blockers in hippocampal neurons | N. I. Kiskin, O. A. Kryshtal, A. Y. Tsyndrenko, T. M. Volkova, E. V. Grishin, Neurophysiology 1990, 21, 525-532 | A. lobata | Argiopinin 4 | Activity-studies | Link |
| Polyamine toxins from spiders and wasps | A. Schäfer, H. Benz, W. Fiedler, A. Guggisberg, S. Bienz, M. Hesse, The Alkaloids 1994, 45, 1-125 | A. lobata | Arg 630 / Argiopinin 4 | Review | Link |
| Acylpolyamines: Mass spectrometric analytical methods for Araneidae spider acylpolyamines | Y. Itagaki , T. Nakajima , Toxin Rev. 2000, 19, 23-52 | A. lobata | Arg 630 | Review | Link |
Spider species
| Spider species | Family | Discovered |
|---|
| Argiope lobata | Araneidae | 1988 / E. V. Grishin |