4-OH-IndAcAsn3(Me)4(Me)3Arg
4(Me)3Arg.png)
General Description
| Name | Value |
|---|---|
| Level | S-1 / C-3 |
| Discovered | 1987 / A. aurantia |
| Synonym | AR 673 / Arg 673 / ArgTX 673 |
| Molecular formula | C₃₂H₅₅N₁₁O₅ |
| CAS | 769084-09-5 |
| SMILES | O=C(CC1=CNC2=C1C(O)=CC=C2)NC(CC(N)=O)C(NCCCN(C)CCCCN(C)CCCNC(C(CCCNC(N)=N)N)=O)=O |
| InChI | InChI=1S/C32H55N11O5/c1-42(17-7-13-37-30(47)23(33)9-6-12-39-32(35)36)15-3-4-16-43(2)18-8-14-38-31(48)25(20-27(34)45)41-28(46)19-22-21-40-24-10-5-11-26(44)29(22)24/h5,10-11,21,23,25,40,44H,3-4,6-9,12-20,33H2,1-2H3,(H2,34,45)(H,37,47)(H,38,48)(H,41,46)(H4,35,36,39) |
| Precursor 1 [M+H]⁺ | 674.44604 |
| Precursor 2 [M+2H]²⁺ | 337.72666 |
| Precursor 3 | |
| HDX | 13 |
| Precursor HDX 1 [M(D₁₃)+D]⁺ | 688.53391 |
| Precursor HDX 2 [M(D₁₃)+2D]²⁺ | 345.27373 |
| Precursor HDX 3 | |
| Rt | |
| Rt HDX |
Calculated MS/MS fragments
| # | a | b | c | ta | z | y | tz |
|---|---|---|---|---|---|---|---|
| 1 | 288.09788 | 270.08732 | 271.07133 | 305.12443 | 214.16624 | 197.13969 | 245.20844 |
| 2 | 345.15573 | 327.14517 | 328.12918 | 376.19793 | 299.25539 | 282.22884 | 330.29759 |
| 3 | 430.24488 | 412.23432 | 413.21833 | 461.28708 | 370.32889 | 353.30234 | 387.35543 |
| 4 | 501.31838 | 483.30782 | 484.29183 | 674.44604 | 484.37181 | 467.34526 | 501.39836 |
Additional MS/MS fragments
| m/z | Annotation |
|---|---|
| 146.06004 | a’ |
| 174.05495 | a0 |
Recorded MS/MS spectra
| Precursor | Co-eluting | Spider | Source | Author | |
|---|---|---|---|---|---|
References
| Title | Reference | Spider | Name | Content | Link |
|---|---|---|---|---|---|
| Structures and biological activities of three synaptic antagonists from orb weaver spider venom | M. E. Adams, R. L. Carney, F. E. Enderlin, E. T. Fu, M. A. Jarema, J. P. Li, C. A. Miller, D. A. Schooley, M. J. Shapiro, V. J Venema, Biochem. Biophys. Res. Com. 1987, 148, 678-683 | A. aurantia | AR 673 | Synthesis, NMR (ns), Amino acid analysis, Activity-studies | Link |
| Isolation and characterisation of glutamate receptor antagonists from venoms of orb-web spiders | T. Budd, P. Clinton, A. Dell, I. R. Duce, S. J. Johnson, D. L. J. Quicke, G. W. Taylor, P. N. R. Usherwood, G. Usoh, Brain Res. 1988, 448, 30-39 | A. florida & A. trifasciata | Arg 673 | cActivity-studies, unknown structure | Link |
| The total synthesis of argiotoxins 636, 659 and 673 | V. J. Jasys, P. R. Kelbaugh, D. M. Nason, D. Phillips, N. A. Saccomano, R. A. Volkmann, Tetrahedron Letters 1988, 29, 6223-6226 | Arg 673 | Synthesis, NMR | Link | |
| Antropod toxins as leads for novel insecticides: An assessment of polyamine amides as glutamate antagonists | I. S. Blagbrough, P. T. H. Brackley, M. Bruce, B. W. Bycroft, A. J. Mather, S. Millington, H. L. Sudan, P. N. R. Usherwood, Toxicon 1992, 30, 303-322 | ArgTX 673 | Review | Link | |
| Polyamine toxins from spiders and wasps | A. Schäfer, H. Benz, W. Fiedler, A. Guggisberg, S. Bienz, M. Hesse, The Alkaloids 1994, 45, 1-125 | div. | AR 673 / Arg 673 / Argiotoxin 673 | Review | Link |
Spider species
| Spider species | Family | Discovered |
|---|---|---|
| Argiope aurantia | Araneidae | 1987 / M. E. Adams |
| Argiope florida | Araneidae | 1988 / T. Budd |
| Argiope trifasciata | Araneidae | 1988 / T. Budd |