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(Acyl)polyamines
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2,4-(OH)₂-PhAc
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2,5-(OH)₂-Bz
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4-OH-Bz
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4-OH-IndAc
-- 4-OH-IndAc3
-- 4-OH-IndAc3(Me₂)4(Me)3(NMe)⁺
-- 4-OH-IndAc3(Me₂)4(Me)3Arg⁺
-- 4-OH-IndAc3(Me₂)4(Me₂)3Arg²⁺
-- 4-OH-IndAc3(Me₂)4(NMe)⁺
-- 4-OH-IndAc3(Me₂)4(NMe₂)⁺
-- 4-OH-IndAc3(OH)3
-- 4-OH-IndAc3(OH)3(OH)33
-- 4-OH-IndAc3(OH)3(OH)34
-- 4-OH-IndAc3(OH)3(OH)343
-- 4-OH-IndAc3(OH)3(OH)35(NMe₃)⁺
-- 4-OH-IndAc3(OH)3(OH)43
-- 4-OH-IndAc3(OH)33
-- 4-OH-IndAc3(OH)333
-- 4-OH-IndAc3(OH)3334Gu
-- 4-OH-IndAc3(OH)334
-- 4-OH-IndAc3(OH)3343
-- 4-OH-IndAc3(OH)3343Ac
-- 4-OH-IndAc3(OH)334Gu
-- 4-OH-IndAc3(OH)335
-- 4-OH-IndAc3(OH)335(NMe)
-- 4-OH-IndAc3(OH)335(NMe₂)
-- 4-OH-IndAc3(OH)335(NMe₃)⁺
-- 4-OH-IndAc3(OH)34
-- 4-OH-IndAc3(OH)343
-- 4-OH-IndAc3(OH)34Gu
-- 4-OH-IndAc3(OH)35(NMe₃)⁺
-- 4-OH-IndAc3(OH)4
-- 4-OH-IndAc3(OH)43
-- 4-OH-IndAc3333
-- 4-OH-IndAc33334Gu
-- 4-OH-IndAc3334
-- 4-OH-IndAc33343
-- 4-OH-IndAc3334Gu
-- 4-OH-IndAc3335(NMe₃)⁺
-- 4-OH-IndAc334
-- 4-OH-IndAc3343
-- 4-OH-IndAc334Gu
-- 4-OH-IndAc335(NMe₃)⁺
-- 4-OH-IndAc34
-- 4-OH-IndAc343
-- 4-OH-IndAc3433
-- 4-OH-IndAc35
-- 4-OH-IndAc353
-- 4-OH-IndAc4(OH)3
-- 4-OH-IndAc4(OH)3(OH)33
-- 4-OH-IndAc4(OH)33
-- 4-OH-IndAc4(OH)333
-- 4-OH-IndAc4(OH)3333
-- 4-OH-IndAc43
-- 4-OH-IndAc433
-- 4-OH-IndAc4333
-- 4-OH-IndAc4Gu
-- 4-OH-IndAc5
-- 4-OH-IndAc5(NMe₃)⁺
-- 4-OH-IndAc5(OH)33
-- 4-OH-IndAc5(OH)3333
-- 4-OH-IndAc53
-- 4-OH-IndAc533
-- 4-OH-IndAc5333
-- 4-OH-IndAcAsn3(Me)4(Me)3Arg
-- 4-OH-IndAcAsn3(Me)43
-- 4-OH-IndAcAsn333
-- 4-OH-IndAcAsn34
-- 4-OH-IndAcAsn343
-- 4-OH-IndAcAsn34ßAla3
-- 4-OH-IndAcAsn34ßAla4
-- 4-OH-IndAcAsn353
-- 4-OH-IndAcAsn4
-- 4-OH-IndAcAsn4(Me)3
-- 4-OH-IndAcAsn43
-- 4-OH-IndAcAsn433
-- 4-OH-IndAcAsn433Arg
-- 4-OH-IndAcAsn433Lys
-- 4-OH-IndAcAsn433ßAla4
-- 4-OH-IndAcAsn433ßAla4ßAla4
-- 4-OH-IndAcAsn43Arg
-- 4-OH-IndAcAsn43Lys
-- 4-OH-IndAcAsn43ßAla4
-- 4-OH-IndAcAsn4Lys(Me₂)3Arg⁺
-- 4-OH-IndAcAsn4ßAla3Arg
-- 4-OH-IndAcAsn4ßAla3ßAla4ßAla4
-- 4-OH-IndAcAsn4ßAla3ßAla4ßAla4ßAla4
-- 4-OH-IndAcAsn4ßAla4
-- 4-OH-IndAcAsn4ßAla43
-- 4-OH-IndAcAsn4ßAla4Arg
-- 4-OH-IndAcAsn4ßAla4ßAla4
-- 4-OH-IndAcAsn5
-- 4-OH-IndAcAsn53
-- 4-OH-IndAcAsn533
-- 4-OH-IndAcAsn533Arg
-- 4-OH-IndAcAsn5Gly4
-- 4-OH-IndAcAsn5Gly4ßAla4
-- 4-OH-IndAcAsn5Gly4ßAla4ßAla4
-- 4-OH-IndAcAsn5Gly4ßAla4ßAla4ßAla4
-- 4-OH-IndAcAsn5Lys(Me)3Arg
-- 4-OH-IndAcAsn5Lys(Me₂)3Arg⁺
-- 4-OH-IndAcAsn5ßAla3
-- 4-OH-IndAcAsn5ßAla3Arg
-- 4-OH-IndAcAsn5ßAla3ßAla4ßAla4
-- 4-OH-IndAcAsn5ßAla3ßAla4ßAla4ßAla4
-- 4-OH-IndAcAsn5ßAla4
-- 4-OH-IndAcAsn5ßAla43
-- 4-OH-IndAcAsn5ßAla43Arg
-- 4-OH-IndAcAsn5ßAla43ßAla4
-- 4-OH-IndAcAsn5ßAla43ßAla4ßAla4
-- 4-OH-IndAcAsn5ßAla4Arg
-- 4-OH-IndAcAsn5ßAla4OrnArg
-- 4-OH-IndAcAsn5ßAla4ßAla4
-- 4-OH-IndAcAsn5ßAla4ßAla4ßAla4
-- 4-OH-IndAcAsn5ßAla4ßAla4ßAla4ßAla4
-- 4-OH-IndAcLysMe53Arg
-- 4-OH-IndAcLysMe₂5(Me)3Arg
-- 4-OH-IndAcOrnAsn5ßAla4ßAla4
-- 4-OH-IndAcOrnAsn5ßAla4ßAla4ßAla4
-- 4-OH-IndAcßAla343
-- 4-OH-IndAcßAla353
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4-OH-PhAc
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4-OH-PhLac
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Ac
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Bz
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IndAc
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IndLac
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OH-OMe-Bz
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PhAc
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Phe
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PhLac
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Prop
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Trp
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Tyr
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Unknown acylpolyamines
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Free polyamines (PA)
Small compounds
Analytical tools
Contact us 4-OH-IndAc3(Me₂)4(Me₂)3Arg²⁺
General Description Name Value Level S-1 / C-1 Discovered 2020 / P. bistriata Synonym Parawixin 10 Molecular formula C₃₀H₅₅N₉O₃²⁺ CAS — SMILES O=C(CC1=CNC2=C1C(O)=CC=C2)NCCC[N+](C)(C)CCCC[N+](C)(C)CCCNC(C(N)CCCNC(N)=N)=OInChI InChI=1S/C30H53N9O3/c1-38(2,19-9-15-34-27(41)21-23-22-37-25-12-7-13-26(40)28(23)25)17-5-6-18-39(3,4)20-10-16-35-29(42)24(31)11-8-14-36-30(32)33/h7,12-13,22,24,37H,5-6,8-11,14-21,31H2,1-4H3,(H5-2,32,33,34,35,36,40,41,42)/p+2Precursor 1 M²⁺ 294.72084 Precursor 2 [(M+H)+CF₃CO₂]²⁺ 351.71700 Precursor 3 [(M+H)+2(CF₃CO₂)]⁺ 816.41740 HDX 10 Precursor HDX M(D₁₀)²⁺ 299.75223 Precursor HDX 2 [(M(D₁₀)+D)+CF₃CO₂]²⁺ 357.25152 Precursor HDX 3 [(M(D₁₀)+D)+2(CF₃CO₂)]²⁺ 827.48644 Rt 6.98 Rt HDX 5.35
Calculated MS/MS fragments # a b c ta z y tz 1 231.11280 213.10224 214.08626 276.17065 214.16624 197.13969 259.22409 2 330.21760 312.20704 313.19105 375.27545 313.27104 297.25231 358.32889 3 415.30675 397.29619 398.28020 588.43441 398.36019 383.34929 415.38673
Additional MS/MS fragments m/z Annotation 146.06004 a’ 174.05495 a0
Recorded MS/MS spectra pdf Precursor Co-eluting Spider Source Author Data 294.72084 P. bistriata Prof. Dr. Wagner Ferreira dos Santos, Y. M. Forster Data 351.71700 P. bistriata Prof. Dr. Wagner Ferreira dos Santos, Y. M. Forster Data 816.41740 P. bistriata Prof. Dr. Wagner Ferreira dos Santos, Y. M. Forster Data HDX P. bistriata Prof. Dr. Wagner Ferreira dos Santos, Y. M. Forster
References Title Reference Spider Name Content Link Neurobiological activity of Parawixin 10, a novel anticonvulsant compound isolated from Parawixia bistriata spider venom (Araneidae: Araneae) H. A. Fachim, A. O. S. Cunha, A. C. Pereira, R. O. Beleboni, L. Gobbo-Neto, N. P. Lopes, J. Coutinho-Netto, W. F. dos Santos, Epilepsy Behav 2011, 22, 158-164 P. bistriata Parawixin10 NMR (ns), Activity-studies, structure unknown Link Neuroprotective activity of Parawixin 10, a compound isolated from Parawixia bistriata spider venom (Araneidae: Araneae) in rats undergoing intrahippocampal NMDA microinjection H. A. Fachim, M. R. Mortari, L. Gobbo-Netto, W. F. dos Santos, Pharmacogn Mag 2015, 11, 579-585 P. bistriata Parawixin10 Activity-studies, structure unknown Link Elucidation of the structure and synthesis of neuroprotective low molecular mass components of the Parawixia bistriata spider venom Y. M. Forster, J. L. Green, A. Khatiwada, J. L. Liberato, P. A. Narayana Reddy, J. M. Salvino, S. Bienz, L. Bigler, W. Ferreira dos Santos, A. C. K. Fontana, ACS Chem Neurosci., 2020 P. bistriata ESI-MS/MS Link
Spider species Spider species Family Discovered Parawixia bistriata Araneidae 2020 / Y. M. Forster
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