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(Acyl)polyamines
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2,4-(OH)₂-PhAc
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2,5-(OH)₂-Bz
-- 2,5-(OH)₂-Bz3
-- 2,5-(OH)₂-Bz3(OH)3(OH)343
-- 2,5-(OH)₂-Bz3(OH)334
-- 2,5-(OH)₂-Bz3(OH)3343
-- 2,5-(OH)₂-Bz3(OH)33433
-- 2,5-(OH)₂-Bz3(OH)334Gu
-- 2,5-(OH)₂-Bz3(OH)335(NMe₃)⁺
-- 2,5-(OH)₂-Bz3(OH)343
-- 2,5-(OH)₂-Bz33(2,5-(OH)₂-Bz)
-- 2,5-(OH)₂-Bz3334
-- 2,5-(OH)₂-Bz33343
-- 2,5-(OH)₂-Bz3334Gu
-- 2,5-(OH)₂-Bz3335(NMe₃)⁺
-- 2,5-(OH)₂-Bz334
-- 2,5-(OH)₂-Bz3343
-- 2,5-(OH)₂-Bz335(NMe₃)⁺
-- 2,5-(OH)₂-Bz34
-- 2,5-(OH)₂-Bz34(2,5-(OH)₂-Bz)
-- 2,5-(OH)₂-Bz343
-- 2,5-(OH)₂-Bz343(4-OH-Bz)
-- 2,5-(OH)₂-Bz3433
-- 2,5-(OH)₂-Bz353(4-OH-Bz)
-- 2,5-(OH)₂-Bz4
-- 2,5-(OH)₂-Bz4(OH)3(OH)33
-- 2,5-(OH)₂-Bz43
-- 2,5-(OH)₂-Bz433
-- 2,5-(OH)₂-Bz4333
-- 2,5-(OH)₂-Bz43333
-- 2,5-(OH)₂-Bz4333Ac
-- 2,5-(OH)₂-Bz4Gu
-- 2,5-(OH)₂-Bz5
-- 2,5-(OH)₂-Bz5(OH)33
-- 2,5-(OH)₂-Bz5333
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4-OH-Bz
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4-OH-IndAc
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4-OH-PhAc
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4-OH-PhLac
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Ac
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Bz
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IndAc
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IndLac
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OH-OMe-Bz
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PhAc
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Phe
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PhLac
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Prop
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Trp
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Tyr
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Unknown acylpolyamines
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Free polyamines (PA)
Small compounds
Analytical tools
Contact us 2,5-(OH)₂-Bz34(2,5-(OH)₂-Bz)
General Description Name Value Level S-2 / C-1 Discovered 2020 / P. bistriata Synonym Mygalin Molecular formula C₂₁H₂₇N₃O₆ CAS 925223-64-9 SMILES O=C(C1=C(O)C=CC(O)=C1)NCCCNCCCCNC(C2=C(O)C=CC(O)=C2)=OInChI InChI=1S/C21H27N3O6/c25-14-4-6-18(27)16(12-14)20(29)23-10-2-1-8-22-9-3-11-24-21(30)17-13-15(26)5-7-19(17)28/h4-7,12-13,22,25-28H,1-3,8-11H2,(H,23,29)(H,24,30)Precursor 1 [M+H]⁺ 418.19726 Precursor 2 [M+2H]²⁺ 209.60227 Precursor 3 HDX 7 Precursor HDX 1 [M(D₇)+D]⁺ 426.24748 Precursor HDX 2 [M(D₇)+2D]²⁺ 214.13051 Precursor HDX 3 Rt 20.27 Rt HDX 18.35
Calculated MS/MS fragments # a b c ta z y tz 1 194.08117 176.07060 177.05462 211.10772 208.09682 191.07027 225.12337 2 265.15467 247.14410 248.12812 418.19726 265.15467 248.12812 282.18122
Additional MS/MS fragments Recorded MS/MS spectra pdf Precursor Co-eluting Spider Source Author Data 418.19726 P. bistriata Prof. Dr. Wagner Ferreira dos Santos, BRA Y. M. Forster Data HDX P. bistriata Prof. Dr. Wagner Ferreira dos Santos, BRA Y. M. Forster
References Title Reference Spider Name Content Link Structural and biological characterization of one antibacterial acylpolyamine isolated from the hemocytes of the spider Acanthocurria gomesiana L. S. Pereira, P. I. da Silva Jr., M. T. M. Miranda, I. C. Almeida, H. Naoki, K. Konno, S. Daffre, Biochemical and Biophysical Research Communications 2007, 352, 953-959 A. gomesiana hemocytes: NMR, ESI-MS/MS, Activity-studies Link The spider acylpolyamine mygaline is a potent modulator of innate immune responses D. G. Mafra, P. I. da Silva Jr., C S. Galhadro , R. Nassar, S. Daffre, M. N. Sato, M. M. Borges, Cellular Immunology 2012, 275, 5-11 A. gomesiana hemocytes: Activity-studies Link Mygalin: A new anticonvulsant polyamine in acute seizure model and neuroethological schedule L. D. Godoy, J. L. Liberato, P. I. da Silva Jr., W. F. dos Santos, Central Nervous System Agents in Medicinal Chemistry 2013, 13, 122-131 Mygalin Activity-studies Link Elucidation of the structure and synthesis of neuroprotective low molecular mass components of the Parawixia bistriata spider venom Y. M. Forster, J. L. Green, A. Khatiwada, J. L. Liberato, P. A. Narayana Reddy, J. M. Salvino, S. Bienz, L. Bigler, W. Ferreira dos Santos, A. C. K. Fontana, ACS Chem Neurosci., 2020 P. bistriata ESI-MS/MS Link
Spider species Spider species Family Discovered Parawixia bistriata Araneidae 2020 / Y. M. Forster
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