Chemical structure of Joro spider toxin (JSTX) | Y. Aramaki, T. Yasuhara, K. Shimazaki, N.i Kawai, T. Nakajima, Biomed. Res. 1987, 8, 241-245 | N. clavata | JSTX 3 | NMR (ns), Amino acid analysis | Link |
Synthesis of spider toxin (JSTX-3) and its analogs | Y. Hashimoto, Y. Endo, K. Shudo, Y. Aramaki, N. Kawai, T. Nakajima, Tetrahedron Letters 1987, 28, 3511-3514 | | JSTX 3 (1) | Synthesis, NMR, Activity-studies | Link |
Newly synthesized analogues of the spider toxin block the crustacean glutamate receptor | K. Shudo, Y. Endo, Y. Hashimoto, Y. Aramaki, T. Nakajima, N. Kawai, Neuroscience Research 1987, 5, 82-85 | N. clavata | JSTX 3 | Activity-studies | Link |
Isolation and characterization of spider toxin, JSTX and NSTX, in the venom of Nephila clavata and N. maculata | Y. Aramaki, T. Yasuhara, N. Kawai, T. Nakajima, Peptide Chemistry 1988, 163-166 | N. clavata & N. maculata | | | |
Ionidated Joro toxin (JSTX-3). Its structure and binding to the lobster neuromuscular synapse | K. Hagiwara, Y. Aramaki, K. Shimazaki, N. Kawai, T. Nakajima, Chem. Pharm Bull. 1988, 36, 1233-1236 | | iodinated JSTX 3 | Activity-studies | Link |
Synthesis of neurotoxic Nephila spider venoms: NSTX-3 and JSTX-3 | D. M. Nason, V. J. Jasys, P. R. Kelbaugh, D. Philips, N. A. Saccomano, R. A. Volkmann, Tetrahedron Letters 1989, 30, 2337-2340 | | JSTX 3 | Synthesis, NMR | Link |
A spider toxin (JSTX)-binding protein in rat hippocampus | K. Shimazaki, K. Hagiwara, N. Kawai, T. Nakajima, Biomedical Research 1989, 10, 401-403 | | JSTX 3 | Activity-studies | Link |
Acylpolyamines mimic the action of Joro spider toxin (JSTX) on crustacean muscle glutamate receptors | T. Asami, H. Kagechika, Y. Hashimoto, K. Shudo, A. Miwa, N. Kawai, T. Nakajima, Biomedical Research 1989, 10, 185-189 | | JSTX | Activity-studies | Link |
Zinc ion enhances the blocking potency of synthetic analogs of spider toxin (JSTX) on the glutamate receptor | N. Kawai, A. Miwa, Y. Hashimoto, K. Shudo, T. Asami, T. Nakajima, Neuroscience Research 1989, 6, 358-362 | | JSTX 3 | Activity-studies | Link |
Argiopine, argiopinines, and pseudoargiopinines as glutamate receptor blockers in hippocampal neurons | N. I. Kiskin, O. A. Kryshtal, A. Y. Tsyndrenko, T. M. Volkova, E. V. Grishin, Neurophysiology 1990, 21, 525-532 | N. clavata | JSTX 3 | Activity-studies | Link |
Molecular structures of spider toxins (JSTX-1, 2, 3 and 4) in the venom of Nephila clavata L. Koch | T. Toki, T. Yasuhara, Y. Aramaki, Y. Hashimoto, K. Shudo, N. Kawai, T. Nakajima, Jpn. J. Sanit. Zool. 1990, 41, 9-14 | N. clavata | JSTX 3 | Amino acid analysis | Link |
Spider toxins , NSTX and JSTX block synaptic transmission in insect CNS | B. Hue, T. Piek, Comparative Biochemistry and Physiology, Part C: Pharmacology, Toxicology & Endocrinology 1990, 95C, 229-232 | | JSTX 3 | Activity-studies | Link |
Arylamine spider toxins antagonize NMDA receptor-mediated synaptic transmission in rat hippocampal slices | A. L. Mueller, B. C. Albensi, A. H. Ganong, L. S. Reynolds, H. Jackson, Synapse 1991, 9, 244-250 | | JSTX 3 | Activity-studies | Link |
Antropod toxins as leads for novel insecticides: An assessment of polyamine amides as glutamate antagonists | I. S. Blagbrough, P. T. H. Brackley, M. Bruce, B. W. Bycroft, A. J. Mather, S. Millington, H. L. Sudan, P. N. R. Usherwood, Toxicon 1992, 30, 303-322 | | JSTX 3 | Review | Link |
Paralytic effect of spider toxin-related compounds on german cockroach, Blattella germanica L. | T. Toki, A. Miwa, N. Kawai, K. Hagiwara, T. Nakajima, Biomedical Research 1992, 13, 53-58 | | JSTX 3 | Activity-studies | Link |
Finding of primitive polyamine toxins in the venom of a Joro spider, Nephila clavata | T. Chiba, T. Akizawa, M. Matukawa, H. Pan-Hou, M. Yoshioka, Chem. Pharm. Bull 1994, 42, 1864-1869 | N. clavata | JSTX 3 | FAB-MS | Link |
Polyamine toxins from spiders and wasps | A. Schäfer, H. Benz, W. Fiedler, A. Guggisberg, S. Bienz, M. Hesse, The Alkaloids 1994, 45, 1-125 | N. clavata | JSTX 3 | Review | Link |
Structural characterization of glutaminergic blocker spider toxins by high-energy collision charge-remote fragmentations | T. Fujita, Y. Itagaki, H. Naoki, T. Nakajima, Rapid Commun. Mass Spectrom. 1995, 9, 365-371 | | JSTX 3 | CID [M+Na]⁺ | Link |
An efficient synthesis of JSTX-3, a potent neurotoxin of Joro spider (Nephila clavata) | M. Matsushita, T. Kanemura, S. Hatakeyama, H. Irie, T. Toki, M. Miyashita, Tetrahedron 1995, 51, 10687-10698 | | JSTX 3 | Synthesis, NMR | Link |
Effects of a spider toxin and its analogue on glutamate-activated currents in the hippocampal CA1 neuron after ischemia | H. Tsubokawa, K. Oguro, T. Masuzawa, T. Nakaima, N. Kawai, Journal of Neurophysiology 1995, 74, 218-225 | | JSTX | Activity-studies | Link |
Voltage-dependet blockage of Ca2+-permeable AMPA receptors by joro spider toxin in cultured rat hippocampal neurons | M. Iino, M. Koike, T. Isa, S. Ozawa, Journal of Physiology 1996, 496, 431-437 | | JSTX 3 | Activity-studies | Link |
Detection of new spider toxins from a Nephilengys borbonica venom gland using on-line µ-column HPLC continuous flow (FRIT) FAB LC/MS and MS/MS | Y. Itagaki, T. Fujita, H. Naoki, T. Yasuhara, M. Andriantsiferana, T. Nakajima, Nat. Toxins 1997, 5, 1-13 | N. borbonica | JSTX 3 | CID | Link |
Mass spectrometric structure determination of spider toxins: Arginine-containing acylpolyamines from venoms of Brazilian garden spider Nephilengys cruentata | M. S. Palma, Y. Itagaki, T. Fujita, M. Hisada, H. Naoki, T. Nakajima, Nat. Toxins 1997, 5, 47-57 | N. cruentata | | MS/MS | Link |
Diversity of Joro spider toxins | M. Yoshioka, 1997, 117, 700-714 | | JSTX 3 | Review | Link |
Potent and voltage-dependent block by philanthotoxin-343 of neuronal nicotinic receptor/channels in PC12 cells | M. Liu, K. Nakazawa , K. Inoue, Y. Ohno, British Journal of Pharmacology 1997, 122, 379-385 | | JSTX 3 | Activity-studies | Link |
Structural characterization of a new acylpolyaminetoxin from the venom of Brazilian garden spider Nephilenys cruentata | M. S. Palma, Y. Itagaki, T. Fujita, H. Naoki, T. Nakajima, Toxicon 1998, 36, 485-493 | N. cruentata | JSTX 3 | Frit-FAB-MS | Link |
Acylpolyamines: Mass spectrometric analytical methods for Araneidae spider acylpolyamines | Y. Itagaki , T. Nakajima , Toxin Rev. 2000, 19, 23-52 | div. | JSTX 3 | Review | Link |
Long-term potentiation in the presence of NMDA receptor antagonist arylalkylamine spider toxin | B. C. Albensi, N. Alasti, A. L. Mueller, Journal of Neuroscience Research 2000, 62, 177-185 | | JSTX 3 | Activity-studies | Link |
Contribution of Ca2+-permeable AMPA/KA receptors to glutamate-induced Ca2+ rise in embryonic lumbar motoneurons in situ | F. Metzger, A. Kulik, M. Sendtner, K. Ballanyi, Journal of Neurophysiology 2000, 83, 50-59 | | JSTX | Activity-studies | Link |
Novel mechanism of blocking axonal Na+ channels by three macrocyclic polyamine analogues and two spider toxins | M. Yakehiro, Y. Furukawa, T. Koike, E. Kimura, T. Nakajima, K. Yamaoka, I. Seyama, British Journal of Pharmacology 2001, 132, 63-72 | | JSTX 3 | Activity-studies | Link |
Amino acid/spermine conjugates: Polyamine amides as potent spermidine uptake inhibitors | M. R. Burns, C. L. Carlson, S. M. Vanderwerf, J. R. Ziemer, R. S. Weeks, F. Cai, H. K. Webb, G. F. Graminski, J. Med. Chem. 2001, 44, 3632-3644 | | JSTX 3 | Activity-studies | Link |
Effect of two polyamine toxins on the bacterial porin OmpF | A. Basle, A. H. Decour, Biochemical and Biophysical Research Communications 2001, 285, 550-554 | | JSTX | Activity-studies | Link |
An efficient and versatile synthesis of acylpolyamine spider toxins | K. Nihei, M. J. Kato, T. Yamane, M. S. Palma, K. Konno, Bioorg. Med. Chem. Lett. 2002, 12, 299-302 | | JSTX 3 | Synthesis | Link |
A natural combinatorial chemistry strategy in acylpolyamine toxins from Nephilinae orb-web spiders | M. S. Palma, T. Nakajima, Toxin Rev. 2005, 24, 209-234 | div. | JSTX 3 | LC-MS | Link |
Spider polyamine toxin | N. Kawai, Toxicon Review 2005, 24, 273-289 | | JSTX 3 | Review | Link |
The antieptileptic activity of JSTX-3 is mediated by N-methyl-D-aspartate receptors in human hippocampal neurons | S. D. Salamoni, J. C. da Costa, M. S. Palma, K. Konno, K. Nihei, N. A. Azambuja, E. P. Neto, G. T. Venturin, A. A. Tavares, D. S. de Abreu, R. V. Breda, Neuroreport 2005, 16, 1869-1873 | | JSTX 3 | Activity-studies | Link |
Antiepiletipc effect of acylpolyaminetoxin JSTX-3 on rat hippocampal CA1 neurons in vitro | S. D. Salamoni, J. C. da Costa, M. S. Palma, K. Konno, K. Nihei, A. A. Tavares, D. S. de Abreu, G. T. Venturin, F. B. Cunha, R. M. de Oliveira, R. V. Breda, Brain Research 2005, 1048, 170-176 | | JSTX 3 | Activity-studies | Link |
The chelation of metal ions by the acylpolyamine toxins from the web-spider Nephilengys cruentata: effects in the intoxication/detoxification of preys | M. F. Manzoli-Palma, N. Gobbi, M. S. Palma, Chemoecology 2006, 16, 203-208 | N. cruentata | | Synthesis, NMR, Activity-studies | Link |
An efficient and versatile synthesis of all structural types of acylpolyamine spider toxins | K. Nihei, M. J. Kato, T. Yamane, K. Konno, Tetrahedron 2006, 62, 8335-8350 | | JSTX 3 (1) | Synthesis, NMR, ESI-MS/MS | Link |
General synthesis of beta-alanine-containing spider polyamine toxins and discovery of Nephila polyamine toxins 1 and 8 as highly potent inhibitors of ionotropic glutamate receptors | S. Lucas, M. H. Poulsen, N. G. Norager, A. F. Barslund, T. B. Bach, A. S. Kristensen, K. Strømgaard, J. Med. Chem. 2012, 55, 10297-10301 | | JSTX 3 | Synthesis, NMR, Activity-studies | Link |
Structure-activity relationship study of spider polyamine toxins as inhibitor of ionotropic glutamate receptors | X.-F. Xiong, M. H. Poulsen, R. A. Hussein, N. G. Norager, K. Strømgaard, ChemMedChem 2014, 9, 2661-2670 | | JSTX 3 (1) | Synthesis of analogues, Activity-studies | Link |