General Description

LevelS-1 / C-1
Discovered1997 / N. cruentata
SynonymArg 622 / AVTX 622 / NPTX 622 / NPTX 622B
Molecular formulaC₂₈H₅₀N₁₀O₆
CAS345303-38-0 (S,S) / 2133411-64-8 (S,R)
Precursor 1 [M+H]⁺623.39876
Precursor 2 [M+2H]²⁺312.20302
Precursor 3
Precursor HDX 1 [M(D₁₅)+D]⁺639.49918
Precursor HDX 2 [M(D₁₅)+2D]²⁺320.75637
Precursor HDX 3
Rt HDX3.15

Calculated MS/MS fragments


Additional MS/MS fragments


Recorded MS/MS spectra

Data623.39876T. clavipesSpider Pharm, USAY. M. Forster
Data312.20302T. clavipesSpider Pharm, USAY. M. Forster
DataHDXT. clavipesSpider Pharm, USAY. M. Forster


Isolation and characterisation of glutamate receptor antagonists from venoms of orb-web spidersT. Budd, P. Clinton, A. Dell, I. R. Duce, S. J. Johnson, D. L. J. Quicke, G. W. Taylor, P. N. R. Usherwood, G. Usoh, Brain Res. 1988, 448, 30-39A. florida & A. trifasciataArg 622NMR (ns), Amino acid analysis, Activity-studies, partly proposed sructureLink
Polyamine toxins from spiders and waspsA. Schäfer, H. Benz, W. Fiedler, A. Guggisberg, S. Bienz, M. Hesse, The Alkaloids 1994, 45, 1-125A. florida & A. trifasciataArg 622ReviewLink
Mass spectrometric structure determination of spider toxins: Arginine-containing acylpolyamines from venoms of Brazilian garden spider Nephilengys cruentataM. S. Palma, Y. Itagaki, T. Fujita, M. Hisada, H. Naoki, T. Nakajima, Nat. Toxins 1997, 5, 47-57N. cruentataNPTX 622FAB-MS/MSLink
Acylpolyamines: Mass spectrometric analytical methods for Araneidae spider acylpolyaminesY. Itagaki , T. Nakajima , Toxin Rev. 2000, 19, 23-52N. cruentataNPTX 622BReviewLink
Study on the structure activity relationships of NPTX-594, a spider toxin belonging to the type-B acylpolyamine structureT. Wakamiya, T. Kinoshita, Y. Hattori, Y. Yamaguchi, H. Naoki, G. Corzo, T. Nakajima, Bull. Chem. Soc. Jpn. 2004, 77, 331-340NPTX 622BSynthesis, NMR, Activity-studiesLink
A natural combinatorial chemistry strategy in acylpolyamine toxins from Nephilinae orb-web spidersM. S. Palma, T. Nakajima, Toxin Rev. 2005, 24, 209-234div.NPTX 622BLC-MSLink
Structural foundation for insect-selective activity of acylpolyamine toxins from spider Araneus ventricosusK. Lui, M. Wang, L. Jiang, X. Tang, Z. Liu, Z. Zhou, W. Hu, Z. Duan, S. Liang, Chemical Research in Toxicology 2019A. ventricosusAVTX 622NMR, Activity-studiesLink
Low molecular mass compounds in spider venomY. M. Forster, S. Bienz, L. Bigler, 2020, in preparationdiv.Link

Spider species

Spider speciesFamilyDiscovered
Araneus ventricosusAraneidae2019 / K. Lui
Argiope floridaAraneidae1988 / T. Budd
Argiope trifasciataAraneidae1988 / T. Budd
Nephila clavataAraneidae2005 / M. S. Palma
Trichonephila clavipesAraneidae2020 / Y. M. Forster
Trichonephila inaurata madagascariensisAraneidae2005 / M. S. Palma
Nephilingis cruentataAraneidae1997 / M. S. Palma